A Green, Scalable, and Catalyst-Free One-Minute Synthesis of Quinoxalines

Abstract A highly efficient and catalyst-free protocol is reported for the synthesis of quinoxalines via classical cyclocondensation reaction between aryldiamines dicarbonyl compounds. Remarkably simple green conditions employing methanol as solvent afforded medium to excellent yield after only one-minute time at ambient temperature. The allow least 10 gram scale should be a preferred starting point optimization method choice applications in synthetic community.